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Friday, November 2, 2007

Researchers at Case Western University in Cleveland, Ohio have announced the creation of transgenic mice with substantially improved athletic endurance, which live and breed longer and are more aggressive than genetically unmodified siblings, and are leaner despite consuming 60% more food. The mice have been dubbed “mighty mice” or “supermice” by the popular press and have been compared to cyclist Lance Armstrong.

The changes were created by adding an extra copy of a single gene, PEPCK-C. This gene is already present in the mouse genome, but the modified gene is designed to be strongly active (transcribed) in skeletal muscle. (The natural copy of the gene, most active in the liver, continues to function normally). The gene mediates a crucial rate controlling step of gluconeogenesis and glyceroneogenesis, and its activity helps to allow energy production by the mitochondrial citric acid cycle. In the transgenics, more energy is available to muscle through the burning of fatty acids, with much less production of lactate (a chemical that leads to sore muscles when one exercises). This is not as major a change to the mouse genome as it might seem to the layperson. The PEPCK-C gene is already present in the mouse and a variety of natural mutations could likely cause similar results. The study appears today in the Journal of Biological Chemistry in a paper with lead author Parvin Hakimi from the laboratory of Richard W. Hanson.

The altered mice can run at 20 meters per minute (0.75 miles per hour or 1.2 kilometers per hour) for up to six kilometers (nearly four miles) without stopping. The average treadmill time for strenuous exercise on a 25-degree incline is 31.9 minutes, well in excess of the 19 minute average of unmodified mice. Females can breed at two and a half years of age, whereas most female mice cannot breed after the first year.

A colony of 500 mice has been bred, starting from six independent germline transformations (“founder” mice). The level of PEPCK-C in muscle is 9 units per gram of muscle as opposed to only 0.08 in normal mice. Levels of triglycerides and the number of mitochondria are also increased.

Hanson said that he did not expect that the results would be applicable to humans due to both practical and ethical considerations in addition to the fact that the genes might not function the same way in humans.

This is not the first time that the press has dubbed a genetically modified mouse a “mighty mouse”. Earlier scientists at John Hopkins University announced that they had made mice with massively increased muscle mass that were larger and stronger than their normal cousins. These alterations increased strength rather than endurance through the genetic modification of myostatin and follistatin, or by injection of a soluble form of ACVR2B to block myostatin activity in normal mice.

Wednesday, March 1, 2006

The Sizzler Restaurant franchise in Australia has closed the salad bars in all of its 29 restaurants across the country, after rat poison was discovered in food at two of the chain’s outlets in Brisbane. Self-serve salad bars at the restaurants have been closed in response to a sabotage scare. Sizzler Australia Managing Director Bo Ryan said customer safety was always the restaurant chain’s first priority.

A media release on the Sizzler website states: “As a precautionary measure and because customer health and safety is our number one priority, we have temporarily closed salad bars in all Sizzler Restaurants. We sincerely apologise for this major inconvenience.”

Police said green pellets were found in pasta sauce at a Sizzler restaurant in Brisbane’s inner-west on January 20. A regular customer at the Toowong restaurant told Sizzler staff she had found something odd in her bolognese pasta sauce. Similar pellets were found in a vegetable soup at Sizzler’s Myer Centre outlet in the city about 5pm on Saturday.

Bo Ryan said the decision to close all of its Australian salad bars was made after laboratory tests confirmed that the substance in the pasta sauce was indeed rat poison. He said trainees who tasted the poisoned soup had been been taken to hospital by ambulance as a precaution, but had suffered no ill effects.

Queensland Police Inspector Bob Hytch said no one had been reported ill as a result of eating the poisoned food and there had been no extortion threats. Sarah Kenny, a university student, said she and two friends had eaten spaghetti bolognese that “tasted really weird”.

“The inconvenience to customers and the economic impact on the company and its 1600 employees will be severe, but as a family restaurant our first priority is the welfare of our diners,” said Bo Ryan. “Steak and seafood and a limited range of salads would continue to be available.” He hopes that customers will understand the action was taken in their best interests, and that “they can be patient while temporary product security procedures are developed and implemented in all restaurants.”

The 29 Australian Sizzler Restaurants, along with 107 Kentucky Fried Chicken outlets are operated by the Collins Foods Group, a wholly owned subsidiary of Worldwide Restaurant Concepts Inc. Mr Ryan said Sizzler was assessing measures which could be taken to prevent a recurrence of the sabotage. “As soon as new measures are introduced, over and above existing strict protocols, we will reassess the situation,” he said.

Sunday, July 17, 2016

The following is the second edition of a monthly series chronicling the U.S. 2016 presidential election. It features original material compiled throughout the previous month after an overview of the month’s biggest stories.

In this month’s edition on the campaign trail: the effect of the Brexit vote on the US presidential election is examined; a well known businessman and sports team owner pitches his candidacy for vice president; and Wikinews interviews the winner of the American Independent Party California primary.

Friday, August 24, 2007

Atlanta Falcon’s quarterback Michael Vick will enter federal court on Monday, but a newly published report says he will not admit to gambling or killing the dogs. However, Vick is expected to plead guilty to the charge of ‘interstate commerce for the purpose of dogfighting.’

A source told ESPN he did not kill any dogs, but he was present when the dogs were being killed.

Vick faces a maximum of five years in jail. However, a government source told the Associated Press yesterday that prosecutors would most likely recommend a sentence of 12 to 18 months in prison.

Three co-defendants in the case have already pleaded guilty and, if the case goes to trial, will likely testify against Vick.

Vick’s future in the NFL is still uncertain.

Monday, February 20, 2006

The New Zealand government has announced that it will be reviewing funding for medical and dentistry students at Otago and Auckland Universities to certify the institutions’ standards and help staff retention.

The dean of Auckland University’s Faculty of Medical and Health Sciences, Professor Iain Martin says the review “can’t come soon enough”.

The Medical Students Association welcomes the review. It says that it has been worried about student debt for years “High debt encourages too many graduates overseas, or into high paying areas of practice at the expense of areas like general practice”

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Friday, September 7, 2012

London, England — On Wednesday, Wikinews interviewed Duncan Campbell, one of the creators of wheelchair rugby.

((Laura Hale)) You’re Duncan Campbell, and you’re the founder of…

Duncan Campbell: One of the founders of wheelchair rugby.

((Laura Hale)) And you’re from Canada, eh?

Duncan Campbell: Yes, I’m from Canada, eh! (laughter)

((Laura Hale)) Winnipeg?

Duncan Campbell: Winnipeg, Manitoba.

((Laura Hale)) You cheer for — what’s that NHL team?

Duncan Campbell: I cheer for the Jets!

((Laura Hale)) What sort of Canadian are you?

Duncan Campbell: A Winnipeg Jets fan! (laughter)

((Laura Hale)) I don’t know anything about ice hockey. I’m a Chicago Blackhawks fan.

((Hawkeye7)) Twenty five years ago…

Duncan Campbell: Thirty five years ago!

((Laura Hale)) They said twenty five in the stadium…

Duncan Campbell: I know better.

((Hawkeye7)) So it was 1977.

((Laura Hale)) You look very young.

Duncan Campbell: Thank you. We won’t get into how old I am.

((Hawkeye7)) So how did you invent the sport?

Duncan Campbell: I’ve told this story so many times. It was a bit of a fluke in a way, but there were five of us. We were all quadriplegic, that were involved in sport, and at that time we had the Canadian games for the physically disabled. So we were all involved in sports like table tennis or racing or swimming. All individual sports. And the only team sport that was available at that time was basketball, wheelchair basketball. But as quadriplegics, with hand dysfunction, a bit of arm dysfunction, if we played, we rode the bench. We’d never get into the big games or anything like that. So we were actually going to lift weights one night, and the volunteer who helped us couldn’t make it. So we went down to the gym and we started throwing things around, and we tried a few things, and we had a volleyball. We kind of thought: “Oh! This is not bad. This is a lot of fun.” And we came up with the idea in a night. Within one night.

((Hawkeye7)) So all wheelchair rugby players are quadriplegics?

Duncan Campbell: Yes. All wheelchair rugby players have to have a disability of some kind in all four limbs.

((Laura Hale)) When did the classification system for wheelchair rugby kick in?

Duncan Campbell: It kicked in right away because there was already a classification system in place for wheelchair basketball. We knew basketball had a classification system, and we very consciously wanted to make that all people with disabilities who were quadriplegics got to play. So if you make a classification system where the people with the most disability are worth more on the floor, and you create a system where there are only so many points on the floor, then the people with more disability have to play. And what that does is create strategy. It creates a role.

((Hawkeye7)) Was that copied off wheelchair basketball?

Duncan Campbell: To some degree, yes.

((Laura Hale)) I assume you’re barracking for Canada. Have they had any classification issues? That made you

Duncan Campbell: You know, I’m not going to… I can’t get into that in a major way in that there’s always classification issues. And if you ask someone from basketball, there’s classification issues. If you ask someone from swimming… There’s always classification issues. The classifiers have the worst job in the world, because nobody’s ever satisfied with what they do. But they do the best they can. They’re smart. They know what they’re doing. If the system needs to change, the athletes will, in some way, encourage it to change.

((Laura Hale)) Do you think the countries that have better classifiers… as someone with an Australian perspective they’re really good at classification, and don’t get theirs overturned, whereas the Americans by comparison have had a number of classification challenges coming in to these games that they’ve lost. Do you think that having better classifiers makes a team better able to compete at an international level?

Duncan Campbell: What it does is ensures that you practice the right way. Because you know the exact classifications of your players then you’re going to lineups out there that are appropriate and fit the classification. If your classifications are wrong then you may train for six months with a lineup that becomes invalid when that classification. So you want to have good classifiers, and you want to have good classes.

((Laura Hale)) When you started in 1977, I’ve seen pictures of the early wheelchairs. I assume that you were playing in your day chair?

Duncan Campbell: Yes, all the time. And we had no modifications. And day chairs at that time were folding chairs. They were Earjays or Stainless. That’s all the brands there were. The biggest change in the game has been wheelchairs.

((Laura Hale)) When did you retire?

Duncan Campbell: I never retired. Still play. I play locally. I play in the club level all the time.

((Laura Hale)) When did you get your first rugby wheelchair?

Duncan Campbell: Jesus, that’s hard for me to even think about. A long time ago. I would say maybe twenty years ago.

((Laura Hale)) Were you involved in creating a special chair, as Canadians were pushing the boundaries and creating the sport?

Duncan Campbell: To a degree. I think everybody was. Because you wanted the chair that fit you. Because they are all super designed to an individual. Because it allows you to push better, allows you to turn better. Allows you to use your chair in better ways on the court. Like you’ve noticed that the defensive chairs are lower and longer. That’s because the people that are usually in a defensive chair have a higher disability, which means they have less balance. So they sit lower, which means they can use their arms better, and longer so they can put screens out and set ticks for those high point players who are carrying the ball. It’s very much strategic.

((Hawkeye7)) I’d noticed that in wheelchair basketball the low point player actually gets more court time…

Duncan Campbell: …because that allows the high point player to play. And its the same in this game. Although in this game there’s two ways to go. You can go a high-low lineup, which is potentially two high point players and two very low point players, which is what Australia does right now with Ryley Batt and the new kid Chris Bond. They have two high point players, and two 0.5 point players. It makes a very interesting scenario for, say, the US, who use four mid-point players. In that situation, all four players can carry the ball; in the Australian situation, usually only two of them can carry the ball.

((Laura Hale)) Because we know you are going soon, the all-important question: can Canada beat the Australians tonight?

Duncan Campbell: Of course they are. (laughter)

((Laura Hale)) Because Australians love to gamble, what’s your line on Canada?

Duncan Campbell: It’s not a big line! I’m not putting a big line on it! (laughter) I’d say it’s probably 6–5.

((Hawkeye7)) Is your colour commentary for the Canadian broadcast?

Duncan Campbell: That was for the IPC. I did the GB–US game this morning. I do the Sweden–Australia game tomorrow at two. And then I’m doing the US–France game on the last day.

((Laura Hale)) Are you happy with the level of coverage the Canadians are providing your sport?

Duncan Campbell: No.

((Laura Hale)) Thank you for an honest answer.

Duncan Campbell: Paralympic Sports TV is their own entity. They webcast, but they’re not a Canadian entity. Our Canadian television is doing… can I swear?

((Laura Hale)) Yeah! Go ahead!

Duncan Campbell: No! (laughter) They’re only putting on an hour a day. A highlight package, which to me is…

((Hawkeye7)) It’s better than the US.

Duncan Campbell: Yes, I’ve heard it’s better than the US. At the same time, it’s crap. You have here [in Great Britain], they’ve got it on 18 hours a day, and it’s got good viewership. When are we going to learn in North America that viewership is out there for it? How many times do we have to demonstrate it? We had the Paralympics in Vancouver two years ago, the Winter Paralympics, and we had crappy coverage there. There was an actual outburst demand to put the opening ceremonies on TV because they weren’t going to do it. And they had to do it, because everybody complained. So they did it, but they only did it in BC, in our home province, where they were holding it. The closing ceremonies they broadcast nationally because the demand was so high. But they still haven’t changed their attitudes.

((Laura Hale)) I have one last question: what did it mean for you when they had a Canadian flag bearer who was a wheelchair rugby player?

Duncan Campbell: I recruited that guy. It was fantastic. I recruited him. Found him playing hockey. And that guy has put in so much time and effort into the game. He absolutely deserves it. No better player.

((Laura Hale)) Thank you!

((Hawkeye7)) Thank you! Much appreciated.